Gastrointestinal side effects have included , , and diarrhea, and are among the most common side effects associated with cephradine. Several cases of pseudomembranous colitis associated with the use of cephradine have been reported.HypersensitivityHypersensitivity reactions have included rash, , , and joint pain.HematologicHematologic side effects have included transient and mild , and leukopenia.HepaticHepatic side effects have included transient elevations of SGOT, SGPT, and bilirubin. Hepatocellular damage has not been reported.RenalRenal side effects associated with some have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophilia are the hallmarks of cephalosporin-induced interstitial nephritis.)GenitourinaryGenitourinary side effects have included vaginal yeast infections.Nervous systemNervous system side effects have included .OtherOther side effects have included chest tightness.References1. Cannon SR, Dyson PH, Sanderson PJ "Pseudomembranous colitis associated with antibiotic prophylaxis in orthopaedic surgery." J Bone Joint Surg Br 70-B (1988): 600-22. Sankarankutty M, McGeorge D, Galasko CS "Pseudomembranous colitis following cephradine prophylaxis." Postgrad Med J 58 (1982): 726-83. "Product Information. Velosef (cephradine)." Apothecon Inc, Plainsboro, NJ. 4. Klinger D, Radford P, Collin J "Pneumoperitoneum without faecal peritonitis in a patient with pseudomembranous colitis." Br Med J 288 (1984): 1271-25. Roberts AP, Hughes AW "Complications with antibiotics used prophylactically in joint replacement surgery." Int Orthop 8 (1985): 299-3016. Kalb RE, Grossman ME "Pustular eruption following administration of cephradine." Cutis 38 (1986): 58-607. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 2268. Lawson A, McArdle T, Ghosh S "Cephradine-associated immune neutrophenia." N Engl J Med 312 (1985): 651Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.. Uses of Velosef 500mg. This medicine is used in lung infections, stomach problems, in septicaemia (blood poisoning by bacteria), surgery, endocarditis (infection in the heart), urinary tract infections, skin infection and soft tissue infections..